pentobarbital will reduce the level or influence of theophylline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.pentobarbital decreases levels of vandetanib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Avoid coadministration with potent CYP3A4 inducers; these drugs lower publicity to vandet… Read More